By experimental data, characteristic of film hole single-line interference infiltration was analyzed. The three mathematical models of film hole single-line interference infiltration were proposed under different conditions of known data. Model 1 is based on that the parameters of the reduced infiltration volume that film hole single-line interference infiltration as compared with film hole free infiltration and of the film hole free infiltration are known; Model 2 is based on that the infiltration parameters of two stages of film hole single-line infiltration——film hole free infiltration and interference infiltration are known; Model 3 is based on that the rate of reduced infiltration that film hole single-line interference as compared with film hole free infiltration and the parameter of free infiltration are known. The calculation precision of the model was verified by experimental data. The results provide reference for further study of film hole irrigation.