The paper analyses status quo and some present problems of aquiculture in China, and then presents design methods of the supervision and control system with multi-environmental factors of aquiculture, which uses a PC as a host computer and some S7-224 programmable logic controller as secondary computers, and the system was successfully applied in industrialized production of eel. The test results proved, that the system was operated simply, had a good interface and had a high ratio of performance to price. It can realize realtime control over quantity of dissolvent Oxygen in pond, and the value of temperature and pH, and make environmental factors stabilize in its optimum. The whole system can improve productivity remarkably, save power energy and provide a practicable measures for improving industrialized breeding in China.