In view of the shortcomings of greasing to lubricating points of vehicle chassis by hand at present, the principle and techniques of the auto-centralized grease lubrication system were studied. The technical parameters of key parts, such as geared pump, pressure limiting valve, re-greasing distributor and pipe connector were obtained and the methods of structure design were presented in this paper. The results of prototype tests show that the centralized grease lubrication system has met the design requirement of the vehicle chassis lubrication supplied from 30 to 60 points, and the technical parameters such as the output pressure and amount of grease supplied by greased pump and re-greasing distributor have reached the design standards. The performance tests of practical application show that the greasing equipment has stable operation and high quality of distributing grease, which can be extended to commercial vehicles, agriculture machinery and construction machines. Thus, the design method presented in this paper is reasonable and feasible.