A study on the precision cotton growing in Shihezi Experimental Area in Xinjiang was carried out based on the characteristics of the mechanized, intensive and large-scaled production and the consideration of the actuality and basic conditions of cotton growing in Xinjiang Group Company of Production and Construction by using the new technology, conception, ways and means of GIS, RS, GPS, ES and MS. After following up the advanced study achievements and development level of domestic and foreign precision agriculture, the characteristic digital farming system and popularization mode were developed by completing, developing and integrating the available farming devices in Xinjiang based on the innovation of digital farming technologies and the integration of domestic available research achievements and technologies as well as the information technology, and a large-scaled application demonstration was carried out. After making great efforts under the cooperation with some units, a study on the integration of information system for the precision cotton growing was carried out in three aspects including the farmland information collection system, information processing system and implementation system, and some preliminary achievements have been achieved. These achievements were applied in the management decision-making of the integrated and completed technological system, precision cotton seeding, water-saving irrigation, variable fertilization, prediction and control of plant diseases and insect pests, cotton growth monitoring, etc. based on the developed and introduced hardware platform. Thus, a set of advanced, matured and intellectualized decision-making systems for precision cotton growing and management were formed, which were suitable for cotton growing in Xinjiang, and those were integrated with the variable farming devices in the demonstration. The achievements in this study can be referred in precision cotton growing in Xinjiang and other regions in China, they have popularization significances in Xinjiang and even in other provinces of China, and the market potential is huge.