Agricultural non-point source pollution is a kind of complex process with the characteristics of intermittent, random, sudden and uncertain emergence. Thus, the modeling study is an important content in the field of non-point source pollution at all times. This paper reviews the development of the prediction model of agricultural non-point source pollution, briefly illustrates the function and research advances of foreign agricultural non-point source models at the field scale and watershed scale, discusses the prediction, model development and available problems of non-point source pollution in China. It is proposed that the study of pollutant transport and prediction model should be based on the point of view of integrated agricultural production and water environmental protection. And one of main contents of non-point source pollution is to consider the uncertain characteristics of non-point source pollution and to combine 3S techniques with non-point source model.