Based on single factor experiment and results analysis of influences on burdock fine pulverizing, quadratic regression orthogonal experiment was carried out for studying effect of ball mill rotation speed, pulverizing time, medium filling rate and material filling rate on pulverizing criteria such as powder granularity and unit powder energy consumption, and regression mathematical models describing relations between experimental factors and pulverizing criteria were established. Using multi-goal non-linear optimizing method, optimal combination of technological parameters for burdock fine pulverizing was determined with ball mill rotation speed 272 r/min, pulverizing time 85 min, material filling rate 13% and medium filling rate 12%, which achieved minimum unit powder energy consumption 0.002 kW·h/g. The optimal technological parameters have an instructional significance for burdock fine pulverizing with ball mill.