The process parameters for ramie peeling are the fundamental guarantee for peeling machine design and mechanical analysis. According to the characteristics of mechanical and cutting mechanism movement of peeling ramie machine, ramie peeling experiment was designed and carried out for improving the peeling quality and efficiency. The authors determined the basic process parameters, the mechanical and physical properties of ramie bark and analyzed the relationship of those parameters with peeling. The experimental results showed that with the pressure increasing, the contents of the trash and colloid in fibers were reduced, and the quality of ramie fibers was improved, but the loss rate was increased. The increase of cutting velocity of ramie bark would help improving work efficiency, but the quality of ramie fibers, however, was significantly reduced and the loss rate was increased. The analysis of the effects on peeling quality and production efficiency showed that the best value of the positive pressure and the cutting velocity were 220 N and 0.6 m/s, respectively. The processing parameters such as sliding friction coefficient, the shear strength of ramie shell and the thickness compression ratio of ramie shell and fiber were the important references for cutting mechanism design of the ramie peeling machine.