Abstract: Along with China methane industry development, processing and utilization of biogas residue is an urgent need. Past studies show that biogas residue fertilizer is a high quality liquid organic fertilizer and biological pesticide. Biogas residue fertilizer transportation and fertilization in the field need biogas residue fertilizer transport tank truck. While the acres of the fertilizer application rate in the field are as high as 50 t/hm2, thus in order to improve the shipments and using efficiency of tank truck, development of a large-scale biogas residue tank truck is essential. During transportation of biogas residue fertilizer, tankers will experience starting, acceleration, constant speed, the emergency brakes driving conditions. When the tanker driving state changed, biogas residue fertilizer is forced by inertial to cause rock, which has the impact to the storage tank wall surface, and the oversized impulse causes the storage tank structure to be damaged, resulting to biogas fertilizer leakage, which brings the danger for the safe transportation. However in the driving conditions, emergency brake driving conditions will lead to the biggest damage to the tank. When a large tanker for carrying biogas residue fertilizer suffers emergency braking in its transportation of biogas fertilizer, the huge attack on the wall from biogas fertilizer's violent sway may result in damage on tank and its structure, which causes potential crisis on safety in transportation. In this paper, our results showed that the best transportation filling ratio for a tanker was in the range of 0.8?0.9 by making an analysis and numerical simulation of biogas fertilizer's sway in the tank in different filling ratios when tanker was emergently braked using VOF multiphase flow model. We established a finite element model in which there was a link-up and force delivery among components on a 3D model using CATIA finite element analysis module. We calculated the basis of tanker's actual working condition, restriction implemented and the maximum loading limit of the attack that the tanker's front seal and front washboards can support. Then we adjust tank's design and refined structure according to the computation result, and concluded that the deformation and string of tank was 6.25 mm and 136 MPa respectively. After that, we defined the geometry size and experiment parameters of tank model using dimensional analysis method of the similar theory. When the parameter design was finished, we carried out the prototypical tank trial manufacturing. After that, a high-speed camera was used to shoot biogas residue flow state in different filling ratio of the tank and at the same time high-frequency dynamic response of the pressure sensor was used to test wave proof plate. In the experiment, it was calculated that the ratio of attack from the peak surface of front washboard and the numerical simulation result in prototype was nearly 1:64, which meant that the experiment result can be applied on prototype. This paper provided accessible solution for design of large tanker's tank which carried biogas residue fertilizer and provided reference for design of tank of similar transportation tankers.