Abstract: Multifunctional Agriculture (MFA) management has been increasingly important for sustainable cropland utilization in recent years. The farmland loss and changing agricultural activities have posed serious impacts on the structure and functions of cropland in the rapid urbanization. Therefore, it is necessary to explore the spatial-temporal evolution characteristics, the trade-off and synergy relationships of multifunctional cropland. In this study, taking Zhejiang Province, a representative region with rapid social-economic development in China as an example, a series of widely used quantitative methods were employed to systematically evaluate cropland multifunctional value on the county scale. According to four dimensions of cropland production, ecological, social, and cultural functions, eight main functions of cropland were identified, including food production, atmosphere regulation, environmental purification, water conservation, biodiversity, agricultural pollution, social security, and cultural leisure. Spearman's rank correlation coefficient method, bivariate local spatial autocorrelation model and Stochastic Impacts by Regression on Population Affluence and Technology (STIRPAT) model were used to investigate the trade-off and synergy relationships among cropland multifunctions, and the social-economic driving factors. The data was collected from Zhejiang Statistical Yearbook (2001-2016); digital land use/cover maps for 2000, 2010 and 2015 were obtained from the Chinese Ministry of Environmental Protection; the precipitation data came from the National Meteorological Information Center; and the soil type data of Zhejiang Province was from the second soil survey database of China. The results showed that: 1)the total value of cropland multifunctionality displayed a declined trend during 2000 and 2015, while the value of cropland multifunctionality per hectare decreased first and then gradually increased. The value of atmospheric regulation, water conservation and social security decreased significantly. Meanwhile, the value of food production remained constant, whereas, the value of cultural leisure increased rapidly. The total value of cropland multifunctionality showed different spatial characteristics, indicating high values in the north, but low in the south of Zhejiang Province. In the counties, Hangzhou City showed the highest value, while the lowest value was in Shengsi County. The cropland multifunctional value decreased in many counties to some degree, but the value increased dramatically in the southwest mountainous areas. 2) Synergy relationships were dominant among cropland multifunction, showing spatial heterogeneity. The high-high synergy areas were distributed in Hangzhou and Shaoxing cities, while the low-low synergy areas were clustered in Lishui and Quzhou cities in southwestern Zhejiang Province, where the low-high and high-low trade-off areas were distributed around the synergy areas. During 2000 and 2015, synergy relationships among cropland multifunctions totally weakened, as the decrease in the number of high-high synergy areas. 3) Social-economic system was proved to be related closely with cropland multifunctional value. Specifically, the disposable income of urban residents and the total power of agricultural machinery have negative impacts on the multifunctional value of cropland per hectare. The increase in the disposable income of rural residents can be conducive to promote the multifunctional value of cropland per hectare. It infers that the food production of cropland can be balanced with other functions, including ecological, social, and cultural functions, in order to develop multifunctional agriculture, and further to maximize the human welfare that provided by cropland production system. The findings can provide an important decision-making support to delimit cropland use and protection zone, and further to promote the overall coordinated utilization of multifunctional cropland.